Código: 47650

Código: 47650 – RotaRod NG para Camundongos | Mouse RotaRod

A técnica “Rota-Rod” é essencial na triagem de drogas potencialmente ativas ou com efeitos colaterais na coordenação motora. Ugo Basile projetou o RotaRod original , o primeiro Rota Rod industrial há quase 50 anos, baseado no artigo de 1957 de NW Dunham e TS Miya. O 47650 Rota-Rod NG (Next Generation) , é uma evolução do modelo original e o resultado de muitos anos de pesquisa em cooperação com o mais recente desenvolvimento em pesquisa comportamental e farmacológica.

Desde então, nossos modelos foram citados em milhares de artigos científicos . O nome que cunhamos logo se tornou tão popular, agora todo mundo conhece esse dispositivo como RotaRod!

O que há de novo no modelo NG :

Fisicamente semelhante às versões anteriores, oferece a mesma confiabilidade, combinada com tecnologia inovadora! O novo modelo apresenta caixas de viagem em aço inoxidável para facilitar a limpeza e confinar os animais quando eles caem da haste.

O rato RotaRod consiste em cinco 3cm de diâmetro. cilindros, que são usinados adequadamente para fornecer aderência. Seis 25cm de diâmetro os divisores fazem cinco pistas, cada uma com 5,7 cm de largura, permitindo que cinco camundongos permaneçam no rotor simultaneamente. A altura a cair é de 16 cm.

Um novo software, fácil de usar, está incluído como padrão; Através do novo software, o operador pode organizar facilmente o experimento em seu PC e enviá-lo para o Rota-Rod através da chave USB. O software classifica automaticamente os dados, combinando as configurações com os resultados dos testes; o usuário pode adicionar informações antes ou depois do teste. Os resultados aparecem em uma estrutura semelhante a uma árvore, onde as colunas podem ser arrastadas e soltas para personalizar o layout. Configurações e dados são exportados como relatórios de texto, Excel ou PDF e podem ser salvos na nuvem via DropBox, OneDrive, GoogleDrive.

O experimento pode ser ajustado e os resultados podem ser monitorados, também através da tela sensível ao toque de 4 ”3.

Diagnóstico remoto e acesso à Internet são fornecidos.

O 47650 combina a mesma funcionalidade da versão anterior, agora considerada padrão, com novos recursos adicionais: operação surpreendentemente silenciosa, organização experimental e gerenciamento de dados muito mais fáceis.

CARACTERÍSTICA	BENEFÍCIO
Velocidade ajustável no intervalo 5-80 RPM, em etapas de 1 RPM	Útil em uma variedade de testes
Velocidade constante, rampa (aceleração), rampa com vários passos (NOVO!)	Extrema versatilidade
Novas caixas de viagem	Para envolver os animais, aço inoxidável para facilitar a esterilização
Stick de memória USB embutido	Não requer conexão com o PC (software incluído) para armazenar e transferir dados
Novo software	amigável, incluído como padrão, permite configurar o experimento e gerenciar os resultados do PC ou 4 “3 touch-screen

Geral
Comandos	4 “3 touch-screen (resistivo)
Leia	na tela de toque
Requisito de energia	Entrada universal 85-264 VAC, 50-60Hz, 40W máx.
Nível de som	<60 dB (A)
Temperatura de operação	10 a 40 ° C
Operação
Rapidez	ajustável na faixa de 5-80 RPM, em passos de 1 RPM
Modo	constante, rampa (aceleração), multi-step rampa (NOVO!)
Rotação	para a frente, reverso, balanço
Rotor Iniciar / Parar	na tela de toque
Contando Iniciar / Parar	cada seção através de sua caixa de viagem
Número de pistas	5
Trip-Box	aço inoxidável para facilitar a esterilização
Dirigir	para a frente, reverso, balanço
Aquisição de dados	via software X-PAD, fornecido
Portabilidade de dados	pela unidade flash USB
Saída TTL	para status de faixa, rotação e velocidade
Dados	exportados para texto, Excel ou PDF, ou salvos na nuvem para DropBox, OneDrive, GoogleDrive
Configurações	exportados para texto, Excel ou PDF, ou salvos na nuvem para DropBox, OneDrive, GoogleDrive
Fisica
Peso total	11 kg
Peso	16Kg aprox.
Dimensões	46 (l) x28 (d) x33 (h) cm
Dimensões de Embalagem	70x36x46cm
garantia	47650 é coberto por uma garantia de 24 meses

A técnica “Rota-Rod” foi originada por um artigo de 1957 de NW Dunham e TS Miya (ver parágrafo 9.1 – Artigos de Métodos) e provou ser de grande valor em pesquisas que envolvem triagem de drogas potencialmente ativas em co- motoras. ordenação.

Ugo Basile projetou o primeiro RotaRod industrial nos anos 60. O nome que cunhamos logo se tornou tão popular, agora todo mundo conhece este instrumento como RotaRod!
O Rota-Rod é o teste de referência para triagem de drogas potencialmente ativas, ou com efeitos colaterais, na coordenação motora.

Quando um rato cai da sua seção do cilindro na caixa de desarme abaixo, as caixas de placas e o interruptor magnético correspondente são ativados, registrando assim o tempo de resistência do animal em segundos.

O visor mostra a velocidade real angular (RPM). No final de uma corrida, o visor mostra para cada animal o tempo de execução, o modo de rotação e a velocidade de rotação no momento em que o animal caiu, combinados com informações predefinidas pelo usuário.

47650	Rat RotaRod NG, completo com acessórios padrão
47650-320	Trip-Box de Aço Inoxidável (5 são fornecidos com o pacote padrão)
E-AU 041	Pen drive USB, incluindo: 47750-302 Manual de Instruções Pacote de software X-PAD
OPCIONAL
47850	Combinação Pacote 47650 RotaRod Rato e RotaRod Rato 47750

Bibliografia em 47650

Imagem e avaliação funcional do modelo animal de desestabilização cirúrgica do menisco medial para osteoartrite FBD de Oliveira, JG Souza, O Furiama, M Ferretti … – Osteoartrite e Cartilagem, 2018
A deficiência de seipina em camundongos causa a perda de neurônios dopaminérgicos via agregação e fosforilação de α-sinucleína e neuroinflamação L Wang, Hong Y, Wu, G Liu, L Yu, L Chen – Morte Celular e Doença, 2018 Ratos (seipin-nKO)
A administração da Taurina Recupera os Déficits Motores e de Aprendizagem em um Modelo de Rato com Síndrome de Angelman S Guzzetti, L. Calzari, L. Bucarello, V Cesari, I Toschi… – International Journal of…, 2018
Synthesis and Pharmacological Valorization of Derivatives of 4-Phenyl-1, 5-Benzodiazepin-2-One T Nguema Ongone, R Achour, M El Ghoul, L El Ouasif… – Advances in …, 2018
Kir4. 1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength KW Kelley, LB Haim, L Schirmer, GE Tyzack, M Tolman… – Neuron, 2018
The Blood-Brain Barrier in Neuropsychiatric Disorders C Greene – 2018
Selective spatio-temporal vulnerability of central nervous system neurons to pathological TAR DNA-binding protein 43 in aged transgenic mice A van Hummel, G Chan, J van der Hoven, M Morsch… – The American Journal of …, 2018
Inhibition of Inducible Nitric Oxide Synthase Attenuates Deficits in Synaptic Plasticity and Brain Functions Following Traumatic Brain Injury B Wang, S Han – The Cerebellum, 2018
GABAERGIC LIGANDS AND THEIR USES J Cook, MM Poe, KR Methuku, G Li – US Patent App. 15/560,002, 2018
Preventing muscle wasting by osteoporosis drug alendronate in vitro and in myopathy models via sirtuin‐3 down‐regulation HC Chiu, CY Chiu, RS Yang, DC Chan, SH Liu… – Journal of Cachexia …, 2018
Motor coordination and synaptic plasticity deficits are associated with increased cerebellar activity of NAPDH oxidase, CAMKII, and PKC at pre-plaque stage in the … R Russo, F Cattaneo, P Lippiello, C Cristiano, F Zurlo… – Neurobiology of Aging, 2018
Exercise Ameliorates Motor Deficits and Improves Dopaminergic Functions in the Rat Hemi-Parkinson’s Model YH Chen, TT Kuo, JH Kao, EYK Huang, TH Hsieh… – Scientific Reports, 2018
Ehmt1 forebrain haploinsufficiency leads to impaired memory, sensory gating and information processing BA Davis, F David, C O’Regan, M Adam, A Harwood… – bioRxiv, 2018
Methods for modulating mecp2 expression HY Zoghbi, E Sztainberg, SM Freier – US Patent App. 15/554,407, 2018
Loss of HCN2 leads to delayed gastrointestinal motility and reduced energy intake in mice DW Fisher, P Luu, N Agarwal, JE Kurz, DM Chetkovich – PloS one, 2018
COMPOUNDS FOR THE DIAGNOSIS OR TREATMENT OF DISORDERS ASSOCIATED WITH PROTEIN OR PEPTIDE OLIGOMERS Y Chang, D Su, CL Teoh, S Sahu, T Wisniewski – US Patent App. 15/523,999, 2018
COMPOSITIONS FOR MODULATING MECP2 EXPRESSION SM Freier – US Patent App. 15/554,409, 2018
Intrathecal gene therapy in mouse models expressing CMT1X mutations A Kagiava, C Karaiskos, J Richter, C Tryfonos… – Human Molecular Genetics, 2018
Preconditioning, induced by sub-toxic dose of the neurotoxin L-BMAA, delays ALS progression in mice and prevents Na+/Ca 2+ exchanger 3 downregulation S Anzilotti, P Brancaccio, G Simeone, V Valsecchi… – Cell Death & Disease, 2018
Intrathecal injection of scAAV9-hIGF1 prolongs the survival of ALS model mice by inhibiting the NF-kB pathway HJ Hu, HQ Lin, WS Duan, C Cui, ZY Li, YK Liu… – Neuroscience, 2018
Age-dependent dormant resident progenitors are stimulated by injury to regenerate Purkinje neurons NS Bayin, A Wojcinski, A Mourton, H Saito, N Suzuki… – bioRxiv, 2018
De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination L Montani, JA Pereira, C Norrmén, HBF Pohl, E Tinelli… – J Cell Biol, 2018
Exosome-associated tau exacerbates brain functional impairments induced by traumatic brain injury in mice B Wang, S Han – Molecular and Cellular Neuroscience, 2018
HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease V Benoy, L Van Helleputte, R Prior, C d’Ydewalle… – Brain, 2018
Otud7a knockout mice recapitulate many neurological features of 15q13. 3 microdeletion syndrome J Yin, W Chen, ES Chao, S Soriano, L Wang, W Wang… – The American Journal of …, 2018
Low, but not high, dose triptolide controls neuroinflammation and improves behavioral deficits in toxic model of multiple sclerosis by dampening of NF-κB activation … N Sanadgol, F Golab, A Mostafaie, M Mehdizadeh… – Toxicology and Applied …, 2018
Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer’s disease model F Goñi, M Martá-Ariza, K Herline, D Peyser… – Alzheimer’s Research & …, 2018
A Fragment of Adhesion Molecule L1 Binds to Nuclear Receptors to Regulate Synaptic Plasticity and Motor Coordination K Kraus, R Kleene, M Henis, I Braren, H Kataria… – Molecular Neurobiology, 2018
Anti-inflammatory and antinociceptive properties of the hydroalcoholic fractions from the leaves of Annona crassiflora Mart. in mice C da Costa Oliveira, NA de Matos… – Inflammopharmacology, 2018
Delayed Administration of the Glucagon-Like Peptide 1 Analog Liraglutide Promoting Angiogenesis after Focal Cerebral Ischemia in Mice Y Chen, X Zhang, J He, Y Xie, Y Yang – Journal of Stroke and Cerebrovascular …, 2018
Poor motor-function recovery after spinal-cord injury in anxiety-model mice with phospholipase C–related catalytically inactive protein type 1 knockout T FUJITA, G Kumagai, X LIU, K Wada, T Tanaka… – Journal of Neurotrauma, 2018
BotAF, a new Buthus occitanus tunetanus scorpion toxin, produces potent analgesia in rodents R Maatoug, J Jebali, R Guieu, M De Waard, R Kharrat – Toxicon, 2018
Behavioural phenotypes in mice after prenatal and early postnatal exposure to intermediate frequency magnetic fields K Kumari, H Koivisto, C Myles, N Jonne, V Matti… – Environmental Research, 2018
Chemical characterization, pharmacological effects, and toxicity of an ethanol extract of Celtis pallida Torr.(Cannabaceae) aerial parts EI Rojas-Bedolla, JL Gutiérrez-Pérez, MI Arenas-López… – Journal of …, 2018
Considerations and Pitfalls in Selecting the Drug Vehicles for Evaluation of New Drug Candidates: Focus on in vivo Pharmaco-Toxicological Assays Based on the … M Matias, S Silvestre, A Falcão, G Alves – Journal of Pharmacy & Pharmaceutical …, 2018
Acute and long-term NCX activation reduces brain injury and restores behavioral functions in mice subjected to neonatal brain ischemia P Cerullo, P Brancaccio, S Anzilotti, A Vinciguerra… – Neuropharmacology, 2018
Antideprel jasmonate involves modulation of monoaminergic pathways in mice S Umukoro, A Adebesin, G Agu, O Omorogbe… – Advances in Medical …, 2018
Inflammation and nerve injury minimally affect mouse voluntary behaviors proposed as indicators of pain TD Sheahan, ER Siuda, MR Bruchas, AJ Shepherd, Neurobiology of Pain, 2017
Stereptozotocin-induced Hippocampal Astrogliosis and Insulin Signaling Malfunction as F Rostami, M Javan, A Moghimi, 2017
TARGETED DISRUPTION OF A CSF1-DAP12 PATHWAY MEMBER GENE FOR THE TREATMENT OF NEUROPATHIC PAIN A Basbaum, J Kuhn, Z Guan – US Patent 20,170,354,745, 2017
Defective trafficking of Kv2. 1 channels in MPTP-induced nigrostriatal degeneration RY Chao, CH Cheng, SN Wu, PC Chen, 2017
Motor learning and metaplasticity in striatal neurons: relevance for Parkinson’s disease N Giordano, A Iemolo, M Mancini, F Cacace, M De Risi… – Brain, 2017
Trichloroethylene and Parkinson’s Disease: Risk Assessment M Liu, EJ Shin, DK Dang, CH Jin, PH Lee, JH Jeong… – Molecular Neurobiology, 2017
Treatment with albumin-hydroxyoleic acid complex restores sensorimotor function in rats with spinal cord injury: Efficacy and gene expression regulation. G Avila-Martin, M Mata-Roig, I Galán-Arriero, JS Taylor… – PloS one, 2017
Receptor-interacting protein 140 as a co-repressor of Heat Shock Factor 1 regulates neuronal stress response YL Lin, HC Tsai, PY Liu, M Benneyworth, LN Wei – Cell Death & Disease, 2017
Orai1 plays a crucial role in central sensitization by modulating neuronal excitability Y Dou, J Xia, R Gao, X Gao, FM Munoz, D Wei, Y Tian… – Journal of Neuroscience, 2017
Behavioral testing of mice exposed to intermediate frequency magnetic fields indicates mild memory impairment K Kumari, H Koivisto, M Viluksela, KMA Paldanius… – PloS one, 2017
Control of Huntington’s Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2 LJ Hachigian, V Carmona, RJ Fenster, R Kulicke… – Cell Reports, 2017
Activation of DREAM, a calcium-binding protein, reduces L-DOPA-induced dyskinesias in mice IR De Diego, B Mellstrom, M Vallejo, JR Naranjo, 2017
Rna Interference Suppression Of Neurodegenerative Diseases And Methods Of Use Thereof BL Davidson, H Xia, Q Mao, H Paulson, R Boudreau… – US Patent 20,170,335,318, 2017
Interactions of aliskiren, a direct renin inhibitor, with antiepileptic drugs in the test of maximal electroshock in mice K Łukawski, G Raszewski, SJ Czuczwar – European Journal of Pharmacology, 2017
Aβ oligomer eliminating compounds interfere successfully with pEAβ (3–42) induced motor neurodegenerative phenotype in transgenic mice T Dunkelmann, K Teichmann, T Ziehm, S Schemmert… – Neuropeptides, 2017
Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination MD Grier, KL West, ND Kelm, C Fu, MD Does, B Parker… – PLoS One, 2017
The kinase Fyn as a novel intermediate in L-DOPA induced dyskinesia in Parkinson’s disease S Sanz-Blasco, MP Bordone, A Damianich, G Gomez… – Neurobiology, 2017
Multiple intracerebroventricular injections of human umbilical cord mesenchymal stem cells delay motor neurons loss but not disease progression of SOD1G93A mice F Sironi, A Vallarola, MB Violatto, L Talamini, M Freschi… – Stem Cell Research, 2017
Intranasally Delivered Wnt3a Improves Functional Recovery after Traumatic Brain Injury by Modulating Autophagic, Apoptotic and Regenerative Pathways in the … JY Zhang, J Lee, X Gu, Z Wei, MJ Harris, SPP Yu… – Journal of Neurotrauma, 2017
S-sulfocysteine/NMDA receptor–dependentsignaling underlies neurodegeneration in molybdenum cofactor deficiency A Kumar, B Dejanovic, F Hetsch, M Semtner, D Fusca… – The Journal of Clinical …, 2017
The Enduring Impact of Neurulation Stage Alcohol Exposure: A Combined Behavioral and Structural Neuroimaging Study in Adult Male and Female C57BL/6J Mice EW Fish, LA Wieczorek, A Rumple, M Suttie, SS Moy… – Behavioural Brain Research, 2017
Motor Deficits and Cerebellar Atrophy in Elovl5 Knock Out Mice E Hoxha, R Gabriele, I Balbo, F Ravera, L Masante… – Frontiers in Cellular …, 2017
The adenosine A 2A receptor agonist T1–11 ameliorates neurovisceral symptoms and extends the lifespan of a mouse model of Niemann-Pick type C disease A Ferrante, A Pezzola, A Matteucci, A di Biase, L Attorri… – Neurobiology of Disease, 2017
Pramipexole reduces soluble mutant huntingtin and protects striatal neurons through dopamine D3 receptors in a genetic model of Huntington’s disease D Luis-Ravelo, H Estévez-Silva, P Barroso-Chinea… – Experimental Neurology, 2017
Selective inhibition of M5 muscarinic acetylcholine receptors attenuates cocaine self‐administration in rats BW Gunter, RW Gould, M Bubser, KM McGowan… – Addiction Biology, 2017
ANIMAL MODEL OF LONGEVITY AND RELATED METHODS FOR INCREASING LONGEVITY AND INHIBITING TUMORIGENESIS CJ Shen, Y Shyu – US Patent 20,170,283,477, 2017
DESIGN, SYNTHESIS AND ANTICONVULSANT PROFILE OF 5-(BENZO [D][1, 3] DIOXOL-5-YL)-3-TERT-BUTYL-4, 5-DIHYDROPYRAZOLE DERIVATIVES MF EL-BEHAIRY, HNH ATTIA – 2017
Genetic inactivation of mGlu5 receptor improves motor coordination in the Grm1 crv4 mouse model of SCAR13 ataxia S Bossi, I Musante, T Bonfiglio, T Bonifacino… – Neurobiology of Disease, 2017
Sarm1 Deletion, but Not Wld S, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy J Gilley, RR Ribchester, MP Coleman – Cell Reports, 2017
Fermented Rice Germ Extract Alleviates Morphological and Functional Damage to Murine Gastrocnemius Muscle by Inactivation of AMP-Activated Protein Kinase M Tanaka, Y Yoshino, S Takeda, K Toda, H Shimoda… – J Med Food, 2017
Morin Pretreatment Attenuates Schizophrenia-Like Behaviors in Experimental Animal Models B Ben-Azu, AO Aderibigbe, IA Omogbiya, AM Ajayi… – Drug Research, 2017
Sex-dependent alterations in motor and anxiety-like behavior of aged bacterial peptidoglycan sensing molecule 2 knockout mice T Arentsen, R Khalid, Y Qian, RD Heijtz – Brain, Behavior, and Immunity, 2017
Evolution of anti-parkinsonian activity of monoterpenoid (1R, 2R, 6S)− 3-methyl-6-(prop-1-en-2-yl) cyclohex-3-ene-1, 2-diol in various in vivo models E Valdman – European Journal of Pharmacology, 2017
雷帕霉素对老龄帕金森病模型小鼠线粒体损伤的改善作用张忠霞，马晓伟，王彦永，邱会卿，王铭维 – 中国医科大学学报, 2017
Modulation of GDF11 expression and synaptic plasticity by age and training E De Domenico, G D’Arcangelo, I Faraoni, M Palmieri… – Oncotarget, 2017
Information content of dendritic spines after motor learning D Viggiano, L Speranza, M Crispino, GC Bellenchi… – Behavioural Brain Research, 2017
A Neuron-Specific Gene Therapy Relieves Motor Deficits in Pompe Disease Mice NC Lee, WL Hwu, SI Muramatsu, DJ Falk, BJ Byrne… – Molecular Neurobiology, 2017
Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice F Guida, F Turco, M Iannotta, D De Gregorio, I Palumbo… – Brain, Behavior, and …, 2017
Reward-related limbic memory and stimulation of the cannabinoid system: An upgrade in value attribution? A Brancato, A Cavallaro, G Lavanco, F Plescia… – Journal of …, 2017
Inflammation and nerve injury minimally affect mouse voluntary behaviors proposed as indicators of pain TD Sheahan, ER Siuda, MR Bruchas, AJ Shepherd… – Neurobiology of Pain, 2017
Intranasal Administration of TAT-Conjugated Lipid Nanocarriers Loading GDNF for Parkinson’s Disease S Hernando, E Herran, J Figueiro-Silva, JL Pedraz… – Molecular Neurobiology, 2017
Streptozotocin-induced hippocampal astrogliosis and insulin signaling malfunction as experimental scales for subclinical sporadic Alzheimer model F Rostami, M Javan, A Moghimi… – Life Sciences, 2017
Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders P Schneider, S Petzold, A Sommer, R Nitsch… – Behavioural Brain Research, 2017
The Kinase Fyn As a Novel Intermediate in l-DOPA-Induced Dyskinesia in Parkinson’s Disease S Sanz-Blasco, MP Bordone, A Damianich, G Gomez… – Molecular Neurobiology, 2017
Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source GA Weir, SJ Middleton, AJ Clark, T Daniel, N Khovanov… – Brain, 2017
P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia P Fabbrizio, S Amadio, S Apolloni, C Volonté – Frontiers in Cellular Neuroscience, 2017
NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory N Kessaris, 2017
Sigma-1 receptor knockout increases α-synuclein aggregation and phosphorylation with loss of dopaminergic neurons in substantia nigra J Hong, L Wang, T Zhang, B Zhang, L Chen – Neurobiology of Aging, 2017
AAV9-based gene therapy partially ameliorates the clinical phenotype of a mouse model of Leigh syndrome CF Viscomi, M Zeviani – 2017
Cognitive Impairment and Brain and Peripheral Alterations in a Murine Model of Intraventricular Hemorrhage in the Preterm Newborn A Segado-Arenas, C Infante-Garcia… – Molecular Neurobiology, 2017
Disruption of the ATP/Adenosine Balance in CD39‐/‐Mice is Associated with Handling‐Induced Seizures AJ Lanser, RM Rezende, S Rubino, PJ Lorello… – Immunology, 2017
Pregnane X receptor deletion modifies recognition memory and electroencephalographic activity B Boussadia, L Lakhal, L Payrastre, C Ghosh… – Neuroscience, 2017
Pre-and post-natal melatonin administration partially regulates brain oxidative stress but does not improve cognitive or histological alterations in the Ts65Dn mouse … A Corrales, EB Parisotto, V Vidal, S García-Cerro… – Behavioural Brain Research, 2017
Antinociceptive Activity of Ent‐Dihydrotucumanoic Acid Isolated from Gymnosperma glutinosum Spreng Less AJ Alonso‐Castro, MM González‐Chávez… – Drug Development Research, 2017
Antinociceptive action of NOP and opioid receptor agonists in the mouse orofacial formalin test A Rizzi, C Ruzza, S Bianco, C Trapella, G Calo – Peptides, 2017
Transgenic Mice Overexpressing the Divalent Metal Transporter 1 Exhibit Iron Accumulation and Enhanced Parkin Expression in the Brain CW Zhang, YK Tai, BH Chai, KCM Chew, ET Ang… – NeuroMolecular Medicine, 2017
An Atoh1-S193A phospho-mutant allele causes hearing deficits and motor impairment WR Xie, HI Jen, ML Seymour, SY Yeh, FA Pereira… – Journal of Neuroscience, 2017
Interleukin-1 receptor in seizure susceptibility after traumatic injury to the pediatric brain BD Semple, TJ O’Brien, K Gimlin, DK Wright, SE Kim… – Journal of Neuroscience, 2017
Downregulation of DEC1 contributes to the neurotoxicity induced by MPP+ by suppressing PI3K/Akt/GSK3β pathway Z Zhu, YW Wang, DH Ge, M Lu, W Liu, J Xiong, G Hu… – CNS Neuroscience & Therapeutics, 2017
In-vivo effects of knocking-down metabotropic glutamate receptor 5 in the SOD1 G93A mouse model of amyotrophic lateral sclerosis T Bonifacino, L Cattaneo, E Gallia, A Puliti, M Melone… – Neuropharmacology, 2017, Mouse RotaRod
Viral delivery of C9ORF72 hexanucleotide repeat expansions in mice lead to repeat length dependent neuropathology and behavioral deficits. PJ Gillingwater, M Azzouz, 2017, Mouse RotaRod
Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation E Carboni, L Tatenhorst, L Tönges, E Barski… – NeuroMolecular Medicine, 2017
Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice W Qu, A Johnson, JH Kim, A Lukowicz, D Svedberg… – Journal of …, 2017
The molecular, temporal and region-specific requirements of the beta isoform of Calcium/ Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion MJ Kool, JE van de Bree, HE Bodde, Y Elgersma Page 1. 1 SCIENTIFIC REPORTS | 6:26989 | DOI: 10.1038/srep26989 www.nature.com/
Assessment of Health Risks of Intermediate Frequency Magnetic Fields M Herrala, K Kumari, A Blomme, MW Khan, H Koivisto… – EMBEC & NBC 2017, 2017
Behavioral Effects of a Novel Benzofuranyl-Piperazine Serotonin-2C Receptor Agonist Suggest a Potential Therapeutic Application in the Treatment of Obsessive– … MM Rodriguez, C Overshiner, JD Leander, X Li… – Frontiers in Psychiatry, 2017
HUMAN UMBILICAL CORD BLOOD-DERIVED MONOCYTES FOR TREATMENT OF NEURODEGENERATIVE DISEASES AND DISORDERS J Tan, PR Sanberg – US Patent 20,170,143,769, 2017
Modulation of synaptic plasticity by short-term aerobic exercise in adult mice G D’Arcangelo, T Triossi, A Buglione, G Melchiorri… – Behavioural Brain Research, 2017
Female gonadal hormone effects on microglial activation and functional outcomes in a mouse model of moderate traumatic brain injury O Umeano, H Wang, H Dawson, B Lei, A Umeano… – World Journal of Critical …, 2017
Enriched environment alters the behavioral profile of tenascin-C deficient mice V Stamenkovic, I Milenkovic, N Galjak, V Todorovic… – Behavioural Brain Research, 2017
Lack of riluzole efficacy in the progression of the neurodegenerative phenotype in a new conditional mouse model of striatal degeneration G Kreiner, K Rafa-Zabłocka, P Chmielarz, M Bagińska… – PeerJ, 2017
PER activation is effective in protecting against inflammation-induced nigral dopaminergic loss and motor function impairment J Mendes-Oliveira, FL Campos, RA Videira, G Baltazar – Brain, Behavior, and …, 2017
Geraniin attenuates naloxone-precipitated morphine withdrawal and morphine-induced tolerance in mice EA Kasanga, E Boakye-Gyasi, RP Biney, JO Kyekyek, 2017
Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal TJ Walter, FT Crews – Journal of Neuroinflammation, 2017
JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2 X Zhao, R Wang, J Xiong, D Yan, A Li, S Wang, J Xu… – Toxicology Letters, 2017
Albizia zygia (DC.) JF Macbr.(Leguminosae-Mimosoideae) root extract exhibits anti-nociceptive and antipyretic activities in murine models WKM Abotsi, SB Lamptey, E Boakye-Gyasi, E Woode – Journal of …, 2017
AMYLOID Precursor Protein (APP) Based β-Secretase Inhibitor Peptides, and Methods of Use J Tan, BN Giunta, S LI, H Hou, PR Sanberg – US Patent 20,170,044,225, 2017
APC/CCdh1-Rock2 pathway controls dendritic integrity and memory V Bobo-Jiménez, M Delgado-Esteban, J Angibaud… – Proceedings of the National …, 2017
Behavioural characterization of AnkyrinG deficient mice, a model for ANK3 related disorders IM van der Werf, D Van Dam, S Missault, B Yalcin… – Behavioural Brain Research …, 2017
Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes C Milioto, A Malena, E Maino, MJ Polanco… – Scientific Reports, 2017
Blue light therapy improves circadian dysfunction as well as motor symptoms in two mouse models of Huntington’s disease HB Wang, DS Whittaker, D Truong, AK Mulji, CA Ghiani… – Neurobiology of Sleep and …, 2017
Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein M Tang, G Gao, CB Rueda, H Yu, DN Thibodeaux… – Nature Communications, 2017
Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition MW Breuss, AH Hansen, L Landler, DA Keays – Behavioural Brain Research, 2017
Capsaicin prevents degeneration of dopamine neurons by inhibiting glial activation and oxidative stress in the MPTP model of Parkinson’s disease YC Chung, JY Baek, SR Kim, HW Ko, E Bok, WH Shin… – Experimental & Molecular …, 2017
Dampened amphetamine-stimulated behavior and altered dopamine transporter function in the absence of brain GDNF J Kopra, A Panhelainen, S af Bjerkén, L Porokuokka… – Journal of Neuroscience, 2017
Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation EL Clayton, R Mancuso, TT Nielsen, S Mizielinska… – Human Molecular Genetics, 2017
Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice R Rabl, C Breitschaedel, S Flunkert, S Duller, D Amschl… – BMC Neuroscience, 2017
Effekte der präsymptomatischen Applikation der Rho-Kinase-Inhibitoren Fasudil und Y-27632 im SOD1-(G93A)-Mausmodell der Amyotrophen Lateralsklerose MEH Suhr – 2017
Expression of a Mutant SEMA3A Protein with Diminished Signalling Capacity Does Not Alter ALS-Related Motor Decline, or Confer Changes in NMJ Plasticity after … EB Moloney, B Hobo, F De Winter, J Verhaagen – PloS one, 2017
Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior MA Hutchison, X Gu, MF Adrover, MR Lee, TS Hnasko… – Molecular Psychiatry, 2017
Hip region muscular dystrophy and emergence of motor deficits in dysferlin‐deficient Bla/J mice N Nagy, RJ Nonneman, T Llanga, CF Dial, NV Riddick… – Physiological Reports, 2017
Hypersociability in the Angelman syndrome mouse model DC Stoppel, MP Anderson – Experimental Neurology, 2017
Ketone Supplements For Treatment Of Angelman Syndrome EJ Weeber, SL Ciarlone, DP D’agostino – US Patent 20,170,000,754, 2017
Levetiracetam synergizes with gabapentin, pregabalin, duloxetine and selected antioxidants in a mouse diabetic painful neuropathy model R Stepanović-Petrović, A Micov, M Tomić, U Pecikoza – Psychopharmacology, 2017
Long-term exposure to 835 MHz RF-EMF induces hyperactivity, autophagy and demyelination in the cortical neurons of mice JH Kim, DH Yu, YH Huh, EH Lee, HG Kim, HR Kim – Scientific Reports, 2017
Motor phenotype is not associated with vascular dysfunction in symptomatic Huntington’s disease transgenic R6/2 (160 CAG) mice A Di Pardo, A Carrizzo, A Damato, S Castaldo, E Amico… – Scientific Reports, 2017
Mtss1 promotes maturation and maintenance of cerebellar neurons via splice variant-specific effects T Sistig, F Lang, S Wrobel, SL Baader, K Schilling… – Brain Structure and Function, 2017
Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis D Ditsworth, M Maldonado, M McAlonis-Downes… – Acta Neuropathologica, 2017
Neuregulin-1 mutant Mice indicate motor and sensory deficits, indeed few references for schizophrenia endophenotype model S Schneider, K Götz, C Birchmeier, H Schwegler… – Behavioural Brain Research, 2017
Oral treatment with essential oil of Hyptis spicigera Lam.(Lamiaceae) reduces acute pain and inflammation in mice: Potential interactions with transient receptor … RR Simões, I dos Santos Coelho, SC Junqueira… – Journal of …, 2017
p35 hemizygosity activates Akt but does not improve motor function in the YAC128 mouse model of Huntington’s disease KHJ Park, S Franciosi, K Parant, G Lu, BR Leavitt – Neuroscience, 2017
Pre-clinical therapeutic development of a series of metalloporphyrins for Parkinson’s disease LP Liang, J Huang, R Fulton, JN Pearson-Smith… – Toxicology and Applied …, 2017
Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice E Fucà, M Guglielmotto, E Boda, F Rossi, K Leto… – Neurobiology of Disease, 2017
Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss MH Schludi, L Becker, L Garrett, TF Gendron, Q Zhou… – Acta Neuropathologica, 2017
Substrate Deprivation Therapy to Reduce Glycosaminoglycan Synthesis Improves Aspects of Neurological and Skeletal Pathology in MPS I Mice ALK Derrick-Roberts, MR Jackson, CE Pyragius… – Diseases, 2017
Synthesis and antinociceptive activities of some novel benzimidazole-piperidine derivatives 2 ÜD ÖZKAY, ÖD CAN, N TURAN, B KAYA, 2017
The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression DE Whittaker, KLH Riegman, S Kasah, C Mohan, T Yu… – The Journal of Clinical …, 2017
A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice JR Sheu, ZC Chen, T Jayakumar, DS Chou, TL Yen… – Scientific Reports, 2017
Canales Kv1. 3 median la hiperexcitabilidad de las interneuronas colinérgicas estriatales en un modelo de ratón de la enfermedad de Parkinson C Tubert – 2016
Cytokine therapy‐mediated neuroprotection in a Friedreich’s ataxia mouse model KC Kemp, N Cerminara, K Hares, J Redondo, AJ Cook… – Annals of Neurology, 2016
Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice JA Alfieri, PR Silva, LM Igaz – Frontiers in Aging Neuroscience, 2016
Effects of Conjugated Linoleic Acid Associated With Endurance Exercise on Muscle Fibres and Peroxisome Proliferator-Activated Receptor g Coactivator 1 a Isoforms F. Macaluso – J. Cell. Physiol, 2016
Effects of the synthetic neurosteroid ganaxolone on seizure activity and behavioral deficits in an Angelman syndrome mouse model SL Ciarlone, X Wang, MA Rogawski, EJ Weeber – Neuropharmacology, 2016
Lovastatin fails to improve motor performance and survival in methyl-CpG-binding protein2-null mice C Villani, G Sacchetti, R Bagnati, A Passoni, F Fusco… – eLife, 2016
Neuroprotection in an ALS mouse model following peripheral delivery of motor neuron targeted aCAR-IGF-1 Lentiviral vector I Eleftheriadou, I Manolaras, E Irvine, ND Mazarakis, 2016
Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice JB Zhang, L Chen, ZM Lv, XY Niu, CC Shao, C Zhang… – Molecular Brain, 2016
Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism L Song, M McMackin, A Nguyen, G Cortopassi – Neurobiology of Disease, 2016
Serial in vivo imaging of transplanted allogeneic neural stem cell survival in a mouse model of amyotrophic lateral sclerosis AK Srivastava, SK Gross, AA Almad, CA Bulte… – Experimental Neurology, 2016
Systemic Radical Scavenger Treatment of a Mouse Model of Rett Syndrome: Merits and Limitations of the Vitamin E Derivative Trolox OA Janc, MA Hüser, K Dietrich, B Kempkes… – Frontiers in Cellular …, 2016
The Effects of Synthetic and Dietary Therapeutics on Learning, Memory, Motor Coordination, and Seizure in an Angelman Syndrome Mouse Model SL Ciarlone – 2016
Ultrastructural abnormalities and loss of myelinated fibers in the corpus callosum of demyelinated mice induced by cuprizone Y Xiu, G Cheng, C Peng, Y Wang, Y Li, F Chao, Y Tang – Journal of Neuroscience …, 2016
R.K. Sheean et alia: “Effect of Thymic Stimulation of CD4+ T Cell Expansion on Disease Onset and Progression in Mutant SOD1 Mice” J. Neuroinflammation 12:40, 2015
B.J. Turner et alia: “Overexpression of SurvivaMotor Neuron Improves Neuromuscular Function and Motor Neuron Survivain Mutant SOD1 Mice” Neurobiol. Of Aging 35 (4): 906-915, 2014
M. Milanese et alia: “Knocking Down Metabotropic Glutamate Receptor 1 Improves Survival And Disease Progression in the SOD1G93A Mouse Modeof Amyotrophic LateraSclerosis” Neurobiol. of Disease 64: 48-59, 2014
J.E. Lorenz: “Oxidant-Induced Activation of cGMP-Dependent protein Ki-nase Iα Mediates Neuropathic Pain After PeripheraNerve Injury” Antioxi-dants & Redox Signaling Jan. 2014
C.D. Heldermon et alia: “Therapeutic Efficacy of Bone Marrow Transplant, IntracraniaAAV-mediated Gene Therapy, or Both in the Mouse Modeof MPS IIIB” Molecular Therapy 15(5): 873-880, 2010 (rocking)
C.D. Heldermon et alia: “Development of Sensory, Motor & BehavioraDeficits in the Murine Model of Sanfilippo Syndrome Type B”: PLoS ONE: 8 (e772): 2007 (rocking)

Código: 47650 – RotaRod NG para Camundongos | Mouse RotaRod

Código: 47650

Bibliografia em 47650

Itens relacionados por aplicativo